Roma endured another Old Trafford nightmare last week, losing 6-2 in the Europa League semi-finals.
While not quite as bad as the 7-1, United’s superiority was every bit as emphatic, and there are still 90 minutes of the tie to be played.
Roma were hoping to rebuild their confidence at the weekend, only to lose again.
Paulo Fonseca’s side were beaten 2-0 away at Sampdoria, a side two places below them in the Serie A table.
The result saw defender Gianluca Mancini, who missed the first leg against United due to suspension, offer an apology to fans.
Mancini told TMW: “We did not react and it is right to lose, we must apologise to the fans and try to close the season in the best possible way.”
Manager Paul Fonseca is under pressure for his job now, with the team slipping to seventh in Serie A.
Asked if the team had given up too easily, he told Voce Giallo Rossa: “Yes, it is a difficult time.
“I think we had a good first half after the defeat against Manchester, then we conceded goals before the double whistle and we didn’t have the strength to react.”
Fonseca added that he hoped to get one or two of his injured players back for the second leg, only to suffer another blow.
Goalkeeper Pau Lopez will require surgery, TMW report, after going off injured at Old Trafford.
Lopez sustained a shoulder injury and will undergo an operation this week.
Roma will choose between Antonio Mirante, 37, who came off the bench in the second half at Old Trafford, or Daniel Fuzato.
Fuzato, 23, made his first appearance of the season at the weekend and made an error in the 2-0 loss to Sampdoria.
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