Ole Gunnar Solskjaer has to manage his squad carefully with his team selection against Norwich this Saturday.
United have a tricky away game to take into account with Brighton on Tuesday.
But the FA Cup represents a real chance to win silverware and this is a very winnable tie.
Solskjaer has selected strong teams in domestic cup competitions this season and we expect this to continue.
How many changes?
As we noted yesterday, Solskjaer could make as many as 10 changes to the team which started against Sheffield United.
We expect it will be close, although not quite this many. Our prediction is for seven changes.
We would expect the midfield trio to switch, with Jesse Lingard, Fred and Scott McTominay replacing Bruno Fernandes, Paul Pogba and Nemanja Matic.
It may be easier to run through who we expect to keep their places.
We can see Harry Maguire starting in central defence, partnering Eric Bailly.
Aaron Wan-Bissaka could also get the nod over Diogo Dalot, while we expect Brandon Williams will get a chance at left-back.
In attack United will be wary of making too many changes. Norwich rested attackers Teemu Pukki, Todd Cantwell and Emi Buendia in midweek and all three are expected to play this weekend.
Anthony Martial and Marcus Rashford cut Norwich’s defence to pieces at Carrow Road earlier in the season and we can see them both starting.
Solskjaer should be keen for Rashford to score and get his sharpness back, with the aim of him playing around 60 minutes.
Martial is flying right now and while tempting to bring in Odion Ighalo, an in-form and confident Frenchman could kill the game off early.
Juan Mata and Sergio Romero are both expected to come in for Mason Greenwood and David de Gea.
On the bench
Dan James and Andreas Pereira will be among the substitutes, and there could be a few fresh faces who have not featured in squads yet.
This bench could include youngsters Tahith Chong and James Garner.
Norwich are in really poor form and struggling with injuries defensively, and this could turn into an easy win.
United will have to consider whether to include the likes of Pogba and Fernandes on the bench ‘just in case’, or give them the night off entirely.
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