A heavy dose of rotation is expected when Manchester United take on Derby County tomorrow night.
But how far will Ole Gunnar Solskjaer take it? United are one game away from the quarter-finals, and this is a big opportunity to get closer to a trophy.
David de Gea, Harry Maguire, Bruno Fernandes, Luke Shaw, Nemanja Matic and Anthony Martial could all be rested ahead of the Manchester derby on Sunday.
Dan James and Aaron Wan-Bissaka are also set to miss out due to minor injuries, the club confirmed.
Promising performances from under-23 players on Monday night may put a few of them in contention to feature, although while it may be too soon for Axel Tuanzebe and Timothy Fosu-Mensah to start, they could be in the squad.
A chance for fringe players
Jesse Lingard and Andreas Pereira have struggled for game time in the past few weeks and at times have not even made the matchday squad.
We expect both to start here, with Pereira playing out wide due to a lack of other options, and Lingard centrally.
A midfield of Scott McTominay and iron-man Fred should provide a soli platform for United against the Championship side, who will likely ave Wayne Rooney playing in midfield.
This is a good chance for Odion Ighalo to get up to match fitness, and get onto the scoresheet too.
Brandon Williams has started the last three games on the bench, he should come back in here, and Diogo Dalot will be in at right-back.
We predict Eric Bailly and Victor Lindelöf will start at the back, although brace yourselves, we could get a Phil Jones sighting.
Not starting a full strength XI is a risk, but United have to manage the squad sensibly and the players looked tired in the second half at times against Everton.
It would be good to see James Garner involved after a terrific under-23 performance on Monday. Along with Angel Gomes and Tahith Chong, he could be on the bench.
Here is a look at how we predict United will line up…
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