Both Manchester United and Tottenham have changed their manager since the last meeting between the sides.
In October, Ole Gunnar Solskjaer and Nuno Espirito Santo faced off, but this weekend it will be Ralf Rangnick against Antonio Conte.
This is a huge game in the chase for the top four and United need momentum ahead of the Champions League clash with Atletico Madrid.
We have got everything you need to know about how to watch Manchester United vs Tottenham on TV and online…
When is Manchester United vs Tottenham on TV?
United vs Spurs will take place on Saturday 12th March.
United’s players have had eight days to recover from last weekend’s result, while Spurs were in action against Everton on Monday night, winning 5-0.
What time does Manchester United vs Tottenham kick off?
The game will kick off at 5.30pm.
United won this season’s reverse fixture 3-0 at the Tottenham Hotspur Stadium.
What TV channel is Manchester United vs Tottenham on?
You can watch the game on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HD.
The buildup to the game will start from 5pm.
How to live stream Manchester United vs Tottenham online
Sky Sports customers can live stream the game via the Sky Go app on a variety of devices, including smart phones and tablets.
Highlights will also be available shortly after full-time on Sky Sports Football’s YouTube channel.
Manchester United vs Tottenham team news
Edinson Cavani and Raphael Varane have been pictured training this week after missing the Manchester derby.
Cristiano Ronaldo resumed training on Thursday, according to Ralf Rangnick and all three players are available for selection here.
Luke Shaw also missed the derby and is still positive for Covid and will not play in this one.
Scott McTominay is an injury doubt with a calf problem, with Rangnick saying he is loathe to risk the midfielder ahead of the big game with Atletico Madrid next week.
Manchester United vs Tottenham: Our prediction
United simply have to offer a reaction here in the shape of a big performance.
Tottenham have Harry Kane and Heung-min Son who are in top form right now and ripped United apart on their own patch last season 6-1.
Rangnick has to get a win here. A draw and even a disjointed performance just will not cut the mustard with Atletico Madrid round the corner and the top four slipping away.
We’ll back United to get a victory, and the nature of the display will determine how positive the reaction post-match will be.
Our prediction: Manchester United 2-1 Tottenham